Strategies to ameliorate the cognitive deficits after cranial radiotherapy should therefore likely be adapted to the developmental level of the brain. Little is known about how aging affects the intrinsic properties of the neural stem and progenitor cells NSCs in SVZ and the functional characteristics of their neuronal progeny. Koch, Philipp, et al. Lindvall, Olle författare Cell therapy in Parkinson's disease and stroke Ingår i: Microglia were classified into ramified, amoeboid and round phenotypes based on their morphological characteristics A The percentages of microglia with the different phenotypes of the total number of microglia in sham-irradiated SH or 6 h, 24 h, 7 days and 30 days after IR in juvenile B and adult C brains were assessed. Tillåt minst 24 h för mikrogliaceller att helt återgå till sin förgrenad, vilotillstånd före användning.
Using quantitative PCR, strong short- and long-term increase at 1 and 6 weeks postinfarct of insulin-like growth factor-1 IGF-1 gene expression was detected in SVZ tissue.
Different reactions to irradiation in the juvenile and adult hippocampus
However, when isolated in vitro, the NSCs from SVZ of aged animals have capacity for proliferation and multilineage differentiation, including production of functional neurons, similar to that of NSCs in adult mice, albeit with lower efficacy. Abstract The relative contribution of resident microglia and peripheral monocyte-derived macrophages in neuroinflammation after cranial irradiation is not known. Images from this publication. Använda ett ljusmikroskop bort alla synliga hjärnhinnorna använder microforceps Skär ryggmärgen i tvärgående segment tillräckligt små för att generera flera fragment. The dual role of microglia.
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